The role of platelet-rich plasma (PRP) in treatment of the canine osteoarthritis
Subject Areas : Veterinary Soft and Hard Tissue Surgery
niloofar seydi
1
*
,
Ali Ghashghaii
2
1 - Razi University
2 - Faculty member
Keywords: Canine, orthopedic, PRP,
Abstract :
Osteoarthritis (OA) is a degenerative joint disease accompanied by a progressive reduction of extracellular matrices in joint cartilage and bone and, eventually, loss of joint function and excessive morbidity. OA has been reported in various animal spesies, such as canine. During years, various therapeutic measurs have been used for treating the OA. The purpose of this article is to investigate the role of platelet-rich plasma (PRP) in treatment of the canine osteoarthritis. PRP is the concentration of platelets derived from the plasma portion of one’s own blood. It can be injected in the site of injury, or it can be made into a platelet-rich fibrin clot (PRFC) to use as a scaffold and source for sustained releasing of growth factors. These growth factors reduce the expression of inflammatory cytokines, which dampens the production of destructive matrix. In veterinary medicine, PRP has most often been reported for tendon/ligament injuries and osteoarthritis. The majority of the veterinary literature reporting on PRP involves its use in equine patients, and evidence in canine patients is few. In summary, PRP appears to be safe and potentially useful in treating a number of orthopedic conditions. In vitro data and clinical results in other species are encouraging
1-Pimerattei D, Flo G, Decamp CH. Brinker, Pimerattei, Flo‘s handbook of Small Animal Orthopedis and Fracture Repair. 4th Ed. USA: Saunders Elsevier, St. Louis, Missouri. 2006; 185-202.
2- Todhunter RJ, Johnston SA. Osteoarthritis. In: Slatter D, editor. Textbook of small animal surgery, vol. 2. 3rd edition. Philadelphia: W.B. Saunders Co. 2003; 209-219.
3-Wieland HA, Mechaelis M, Kirshbaun BJ. Osteoarthritis-an untreatable disease? Nat Rev Drug Disc 2005; 4: 331-344.
4-Yamazaki S, Yasuda K, Tomita F, et al. The effect of transforming growth factor-beta1 on intraosseous healing of flexor tendon auto graft replacement of anterior cruciate ligament in dogs. Arthroscopy 2005; 21(9): 1034-41.
5-Zhang J, Wang JH. Platelet-rich plasma releasate promotes differentiation of tendon stem cell into active tenocytes. Am J Sports Med.2010; 38(12):2477-86.
6-Spector TD, MacGregor AJ. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage 2004; 12:S39-44.
7-Valdes AM, Van Oene M, Hart DJ, et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum 2006; 54:533-539.
8-Wonsiewicz M. Repair of full-thickness cartilge defects with cells of different origin in a rabbit model. Arthroscopy 2007; 23(2):178-187.
9- Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 2000; 133(8):635-46
10-Sharma L, Song J, Felson DT, et al. The role of knee alignment in disease progression in Osteoarthritis of the Knee. Arthritis Rheum 2001; 38(6): 760-767.
11- Bonnet DS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology 2005; 44(1): 7-16.
12- Mcllwarith CW and Trotter GW. Joint Disease in the Horse. W.B.Saunders Company. 1996; 29-70.
13-Hashimoto S, Ochs RL, Komiya S , et al. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 1998; 41, 1632–1638.
14-Kempson GE, Muir H, Pollard C, et al. The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans. Biochim Biophys Acta 1973; 465–472.
15- شاه ایوبی م، دباغ آ، ادیب راد م، وزیری ش، اسلامی ب و کریمی افشار س. اثر ترکیبی پلاسمای غنی از پلاکت (PRP) و بیو¬_اس بر بازسازی استخوان سگ در آسیب فورکای درجه دو، بررسی بافت شناسی و هیستومورفومتریک. مجله دندانپزشکی دانشگاه علوم پزشکی شیراز. 1390، دوره دوازدهم، شماره یک، صفحات 1-10.
16- هاشمی م، مددی ف، رضوی س، نیکوسرشت م، حسن زاده کیابی ف و نصیری پور س. مقایسه تأثیر هيالورونيك اسيدودكستروزپرولوتراپي داخل مفصلي دردرمان درداستئوآرتريت زانو. مجله دانشکده پزشکی دانشگاه علوم پزشکی تهران. 1391، دوره 70، شماره 2، صفحات 119-125.
17- Bradley JD, Brandt KD, Katz BP, et al. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 1991; 325:87-91.
18- صفوی زاده ل. مکمل های غذایی در استئوآرتریت. نشریه نوین پزشکی، مقالات مروری. 1386، شماره 415، صفحات 674-680. 19- غلامی خوجین ر. شایع ترین بیماری مفصلی مزمن، تازه های استئوآرتریت. نشریه نوین پزشکی، مقالات مروری. 1390، شماره 508، صفحات 822-833.
20- کمالی ف، ابراهیمی آ، بیات م، ترکمان گ و صلواتی م. اثر لیزر کم توان بر ترمیم آسیب غضروفی-استخوانی مفصل زانوی خرگوش. مجله فیزیک پزشکی ایران. 1384، دوره دوم، شماره 9، صفحات 81-88.
21- مرتضوی م، صادقی پور رودسری غ و بصیرنیا آ. بررسی اثر لیزر کم توان مادون قرمز در بیماران مبتلا به استئوآرتریت زانو. فصلنامه لیزر پزشکی. 1384، دوره چهارم، شماره یک، صفحات 23-26.
22- Everts PA, Knape J, Weirich G, et al. Platelet-rich plasma and platelet gel: A review. JECT 2006; 38; 174-187.
23-Lopez-Vidriero E, Goulding KA, Simon DA, et al. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy 2010; 26(2): 269-78.
24-Lyras DN, Kazakos K, Agrogiannis G, et al. Experimental study of tendon healing early phase: is IGF-1 expression influenced by platelet rich plasma gel? Orthop Traumatol Surg Res 2010; 96(4): 381-7.
25- Alsousou J, Thompson M, Hulley P, et al. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br 2009; 91(8): 987-96.
26- Smith SE, Roukis TS. Bone and wound healing augmentation with platelet-rich plasma. Clin Podiatr Med Surg 2009; 26(4): 559-88.
27- Seydi N, Dehghani S. Effect of platelet rich plasma on guinea pig knee joint osteoarthritis model. OJVR 2017; 21(8):475-483.
28-McCally RE. Platelet Rich Plasma (PRP) in Canine Orthopedics. Available at https://vhc.missouri.edu/platelet-rich-plasma-prp-in-canine-orthopedics/2017.
29- Kazemi D , Fakhrjou A. Leukocyte and Platelet Rich Plasma (L-PRP) Versus Leukocyte and Platelet Rich Fibrin (L-PRF) For Articular Cartilage Repair of the Knee: A Comparative Evaluation in an Animal Model. Iran Red Crescent Med J 2015; 17(10):e19594.
30- Franklin SP, Cook JL. Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs. Can Vet J 2013; 54(9):881–884.