New perspectives in wound management and treatment
Subject Areas : Wound, Complications and Treatments
Saeed Farzad-Mohajeri
1
*
,
Mahdi ghamsari
2
,
Farzad Hayati
3
1 -
2 - Tehran University
3 -
Keywords: Wound healing, Future, Nanotechnology, Biotechnology,
Abstract :
Wound healing has been a major medical challenge in recent decades and it increase motivation of researchers to develop various therapeutic approaches. Along with the latest developments in science and technology, diverse approaches have been created and improved. Although Traditional management, including wound dressings and skin grafts, is still commonly used in current practice but newer technologies found their roles in wound management, such as using stem cells in skin grafts or combining traditional treatments with anti-bacterial nanoparticles. Various upcoming technologies, such as nanotechnology, biotechnology, stem cell therapy and telemedicine have emerged in recent years and are being used to assist wound healing, or even to replace traditional methods. However, many of these methods still lack assessment by large-scale studies and extensive application. Also, studies should design to explore cost-effectiveness, conveniency and efficacy of them. In this review, authors focus on and summarize recent developments involving hi-tech therapeutic methods that lead to both rapid healing and better cosmetic results.
1. Harding KG, Morris HL, Patel GK. Science,
medicine and the future: healing chronic
wounds. BMJ 2002; 324 (7330): 160-163.
2. Gould L, Abadir P, Brem H, et al. Chronic
wound repair and healing in older adults:
Current status and future research. Wound
Repair Regen 2015; 23 (1): 1-13.
3. Dreifke MB, Jayasuriya AA, Jayasuriya AC.
Current wound healing procedures and
potential care. Mater Sci Eng C 2015; 48: 651-
662.
4. Tocco I, Zavan B, Bassetto F, et al.
Nanotechnology-based therapies for skin
wound regeneration. J Nanomater 2012; 1-11.
5. Hussain Z, Thu HE, Ng S-F, et al.
Nanoencapsulation, an efficient and promising
approach to maximize wound healing efficacy
of curcumin: A review of new trends and stateof-
the-art. Colloids Surf B Biointerfaces 2017;
150: 223-241.
6. Chaudhury K, Kumar V, Kandasamy J, et al.
Regenerative nanomedicine: current
perspectives and future directions. Int J
Nanomedicine 2014; 9: 4153-4167.
7. Kalashnikova I, Das S, Seal S. Nanomaterials for
wound healing: scope and advancement.
Nanomedicine 2015; 10 (16): 2593-2612.
8. Moghimi SM, Hunter AC, Murray JC. Longcirculating
and target-specific nanoparticles:
theory to practice. Pharmacol Rev 2001; 53
(2):283-318.
9. Kawai K, Larson BJ, Ishise H, et al. calciumbased
nanoparticles accelerate skin wound
healing. PLoS One 2011; 6 (11): e27106.
10. Sarojini H, Billeter AT, Eichenberger S, et al.
Rapid tissue regeneration induced by
intracellular ATP delivery - A preliminary
mechanistic study. PLoS One 2017; 12 (4): 1-26.
11. Hayati F. Saving zone of stasis in burn wounds
by intracellular delivery of Adenosine
triphosphate: an experimental study in rat.
Submitted to the office of graduate studies in
partial fullfilment of the requirements for the
degree of Doctorate in veterinary surgery.
University of Tehran. 2015; 13-15.
12. Chiang B, Essick E, Ehringer W, et al.
Enhancing skin wound healing by direct
delivery of intracellular adenosine
triphosphate. Am J Surg 2007; 193 (2): 213-218.
13. Brown MS, Ashley B, Koh A. Wearable
technology for chronic wound monitoring:
current dressings, advancements, and future
prospects. Front Bioeng Biotechnol 2018; 6: 47.
14. Sessions JW, Armstrong DG, Hope S, et al. A
review of genetic engineering biotechnologies
for enhanced chronic wound healing. Exp
Dermatol 2017; 26 (2): 179-185.
15. Banerjee J, Chan YC, Sen CK. MicroRNAs in
skin and wound healing. Physiol Genomics
2011; 43 (10): 543-556.
16. Banerjee J, Sen CK. microRNA and Wound
Healing. In: Santulli G, (ed). Advances in
Experimental Medicine and Biology; vol. 888,
Cham: Springer International Publishing, 2015.
p. 291-305.
17. Mulholland EJ, Dunne N, McCarthy HO.
MicroRNA as therapeutic targets for chronic
wound healing. Mol Ther - Nucleic Acids 2017;
8: 46-55.
18. Girard D, Laverdet B, Buhé V, et al.
Biotechnological management of skin burn
injuries: challenges and perspectives in wound
healing and sensory recovery. Tissue Eng Part B
Rev 2017; 23 (1): 59-82.
19. Sorice S, Rustad KC, Li AY, et al. The role of
stem cell therapeutics in wound healing. Plast
Reconstr Surg 2016; 138 (3): 31S-41S.
20. Duscher D, Barrera J, Wong VW, et al. Stem
Cells in wound healing: the future of
regenerative medicine? A mini-review.
Gerontology 2016; 62 (2): 216-225.
21. Augustine R. Skin bioprinting: a novel
approach for creating artificial skin from
synthetic and natural building blocks. Prog
Biomater 2018; 7 (2): 77-92.
22. Téot L. Telemedicine - the future? J Wound
Care 2014; 23 (4): 163.
23. Chanussot-Deprez C, Contreras-Ruiz J.
Telemedicine in wound care: a review. Adv Skin
Wound Care, Vol. 26. 2013. p. 78-82.
24. Sood A, Granick MS, Trial C, et al. The role of
telemedicine in wound care: a review and
analysis of a database of 5795 patients from a
mobile wound-healing center in Languedoc-
Roussillon, France. Plast Reconstr Surg 2016;
138 (3): 248S-256S.
25. Zeng R, Lin C, Lin Z, et al. Approaches to
cutaneous wound healing: basics and future
directions. Cell Tissue Res 2018; 374 (2): 217-
232.